CLEAR CELL ADENOCARCINOMA
\klˈi͡ə sˈɛl ˌadənˌɒkɑːsɪnˈə͡ʊmə], \klˈiə sˈɛl ˌadənˌɒkɑːsɪnˈəʊmə], \k_l_ˈiə s_ˈɛ_l ˌa_d_ə_n_ˌɒ_k_ɑː_s_ɪ_n_ˈəʊ_m_ə]\
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An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.