CLEAR AND PRESENT DANGER

\klˈi͡əɹ and pɹˈɛzənt dˈe͡ɪnd͡ʒə], \klˈi‍əɹ and pɹˈɛzənt dˈe‍ɪnd‍ʒə], \k_l_ˈiə_ɹ a_n_d p_ɹ_ˈɛ_z_ə_n_t d_ˈeɪ_n_dʒ_ə]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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