NEURALGIC MIGRAINE
\njuːɹˈald͡ʒɪk mˈa͡ɪɡɹe͡ɪn], \njuːɹˈaldʒɪk mˈaɪɡɹeɪn], \n_j_uː_ɹ_ˈa_l_dʒ_ɪ_k m_ˈaɪ_ɡ_ɹ_eɪ_n]\
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A syndrome characterized by daily episodes of intense periorbital pain that recur over a period of 6-12 weeks that may be followed by a period of remission of months to years. The pain is non-throbbing, has a duration of 30-60 minutes and tends to occur at night or at regular intervals during the day. Unilateral rhinorrhea, conjunctival injection, lacrimation, facial flushing, and miosis frequently accompany the headaches, which primarily affect young adult males. (Adams et al., Principles of Neurology, 6th ed, p181)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.