OAT CELL CARCINOMAS
\ˈə͡ʊt sˈɛl kˌɑːsɪnˈə͡ʊməz], \ˈəʊt sˈɛl kˌɑːsɪnˈəʊməz], \ˈəʊ_t s_ˈɛ_l k_ˌɑː_s_ɪ_n_ˈəʊ_m_ə_z]\
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An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. There are admixtures of small cell lung carcinoma with other types of lung cancer. Small cell carcinomas are distinguished by their distinctive biological features, response to chemotherapy and radiotherapy, and by their nearly universal tendency to develop overt or subclinical metastases, which frequently eliminates surgery in most patients. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
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