EXPERIMENTAL ALLERGIC NEURITIS
\ɛkspˌɛɹɪmˈɛntə͡l ɐlˈɜːd͡ʒɪk njuːɹˈa͡ɪtɪs], \ɛkspˌɛɹɪmˈɛntəl ɐlˈɜːdʒɪk njuːɹˈaɪtɪs], \ɛ_k_s_p_ˌɛ_ɹ_ɪ_m_ˈɛ_n_t_əl ɐ_l_ˈɜː_dʒ_ɪ_k n_j_uː_ɹ_ˈaɪ_t_ɪ_s]\
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An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84 (1):40-52)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.