COAST AND GEODETIC SURVEY

\kˈə͡ʊst and d͡ʒˌiːə͡ʊdˈɛtɪk sˈɜːve͡ɪ], \kˈə‍ʊst and d‍ʒˌiːə‍ʊdˈɛtɪk sˈɜːve‍ɪ], \k_ˈəʊ_s_t a_n_d dʒ_ˌiː__əʊ_d_ˈɛ_t_ɪ_k s_ˈɜː_v_eɪ]\
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1894 - Dictionary of United States history
By John Franklin Jameson

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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