CAUSE OF ACTION

\kˈɔːz ɒv ˈakʃən], \kˈɔːz ɒv ˈakʃən], \k_ˈɔː_z ɒ_v ˈa_k_ʃ_ə_n]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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