BRAIN ANEURYSMS
\bɹˈe͡ɪn ˈanjuːɹˌɪzəmz], \bɹˈeɪn ˈanjuːɹˌɪzəmz], \b_ɹ_ˈeɪ_n ˈa_n_j_uː_ɹ_ˌɪ_z_ə_m_z]\
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Congenital or acquired abnormal outpouching of an intracranial blood vessel wall. Saccular (berry) aneurysms are the most common variant, and tend to form at arterial branch points near the base of the brain. Rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE (see also OCULOMOTOR NERVE DISEASES). (From Adams et al., Principles of Neurology, 6th ed, p841)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.