KLEINE LEVIN SYNDROME
\klˈe͡ɪn lˈɛvɪn sˈɪndɹə͡ʊm], \klˈeɪn lˈɛvɪn sˈɪndɹəʊm], \k_l_ˈeɪ_n l_ˈɛ_v_ɪ_n s_ˈɪ_n_d_ɹ_əʊ_m]\
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A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.