KIDNEY BRUSH BORDER NEUTRAL PROTEINASE
\kˈɪdnɪ bɹˈʌʃ bˈɔːdə njˈuːtɹə͡l pɹˈə͡ʊtɪnˌe͡ɪs], \kˈɪdnɪ bɹˈʌʃ bˈɔːdə njˈuːtɹəl pɹˈəʊtɪnˌeɪs], \k_ˈɪ_d_n_ɪ b_ɹ_ˈʌ_ʃ b_ˈɔː_d_ə n_j_ˈuː_t_ɹ_əl p_ɹ_ˈəʊ_t_ɪ_n_ˌeɪ_s]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- kidnappings
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- Kidney Brush Border Neutral Proteinase
- kidney calculi
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- kidney calice
- kidney calices
- kidney cancer