GANGLIONIC BLOCKING AGENTS
\ɡˌaŋɡlɪˈɒnɪk blˈɒkɪŋ ˈe͡ɪd͡ʒənts], \ɡˌaŋɡlɪˈɒnɪk blˈɒkɪŋ ˈeɪdʒənts], \ɡ_ˌa_ŋ_ɡ_l_ɪ__ˈɒ_n_ɪ_k b_l_ˈɒ_k_ɪ_ŋ ˈeɪ_dʒ_ə_n_t_s]\
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Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.