FRAMEWORK REGION
\fɹˈe͡ɪmwɜːk ɹˈiːd͡ʒən], \fɹˈeɪmwɜːk ɹˈiːdʒən], \f_ɹ_ˈeɪ_m_w_ɜː_k ɹ_ˈiː_dʒ_ə_n]\
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That region of the immunoglobulin (antibody) molecule that varies in its amino acid sequence and composition, confers the antigenic specificity, and is thought to comprise the binding site for the antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
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