QUALE JUS

\kwˈɒl d͡ʒˈʌs], \kwˈɒl d‍ʒˈʌs], \k_w_ˈɒ_l dʒ_ˈʌ_s]\

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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