MECHANICAL ANTIDOTE

\mɪkˈanɪkə͡l ˈantɪdˌə͡ʊt], \mɪkˈanɪkə‍l ˈantɪdˌə‍ʊt], \m_ɪ_k_ˈa_n_ɪ_k_əl ˈa_n_t_ɪ_d_ˌəʊ_t]\

Definitions of MECHANICAL ANTIDOTE

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1916 - Appleton's medical dictionary
By Smith Ely Jelliffe

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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