EMPLACEMENT
\ɛmplˈe͡ɪsmənt], \ɛmplˈeɪsmənt], \ɛ_m_p_l_ˈeɪ_s_m_ə_n_t]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.