PARACOCCIDIOIDOMYCOSIS
\pˌaɹəkˌɒksɪdɪˌɔ͡ɪdəmɪkˈə͡ʊsɪs], \pˌaɹəkˌɒksɪdɪˌɔɪdəmɪkˈəʊsɪs], \p_ˌa_ɹ_ə_k_ˌɒ_k_s_ɪ_d_ɪ__ˌɔɪ_d_ə_m_ɪ_k_ˈəʊ_s_ɪ_s]\
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A mycosis affecting the skin, mucous membranes, lymph nodes, and internal organs. It is caused by Paracoccidioides brasiliensis. It is also called paracoccidioidal granuloma. Superficial resemblance of P. brasiliensis to Blastomyces brasiliensis (BLASTOMYCES) may cause misdiagnosis.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.