OLIVOPONTOCEREBELLAR ATROPHY
\ˈɒlɪvˌɒpəntˌə͡ʊsɹɪbˌɛləɹ ˈatɹəfi], \ˈɒlɪvˌɒpəntˌəʊsɹɪbˌɛləɹ ˈatɹəfi], \ˈɒ_l_ɪ_v_ˌɒ_p_ə_n_t_ˌəʊ_s_ɹ_ɪ_b_ˌɛ_l_ə_ɹ ˈa_t_ɹ_ə_f_i]\
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A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)
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