MACROGLOBULINEMIA
\mˌakɹəɡlˌɒbjʊla͡ɪnˈiːmi͡ə], \mˌakɹəɡlˌɒbjʊlaɪnˈiːmiə], \m_ˌa_k_ɹ_ə_ɡ_l_ˌɒ_b_j_ʊ_l_aɪ_n_ˈiː_m_iə]\
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A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an IMMUNOGLOBULIN M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. (Dorland, 28th ed)
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