GANGLIONEUROBLASTOMA
\ɡˌaŋɡlɪˌə͡ʊnjuːɹˌɒblastˈə͡ʊmə], \ɡˌaŋɡlɪˌəʊnjuːɹˌɒblastˈəʊmə], \ɡ_ˌa_ŋ_ɡ_l_ɪ__ˌəʊ_n_j_uː_ɹ_ˌɒ_b_l_a_s_t_ˈəʊ_m_ə]\
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A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.